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KMID : 0383819600070020053
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Tuberculosis and Respiratory Diseases
1960 Volume.7 No. 2 p.53 ~ p.56
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Frequency and Rade of Chemotherapeutic Resistant Tubercle Bacilli Observed When Examining T.B Patients.
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한응수(韓膺洙)/Eung Soo Han
김성진(金成鎭)/최석생(崔石生)/Suk Sang Chyo/Sung Chin Kim
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Abstract
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The, frequent appearance of chemotherapeutic agents resistant tubercle bacilli among
T.B patients is becoming a serious public health hazard and a clinically important
problem from the stand-point of evaluating the effectiveness of chemotherapy employed
and in the selection of Anti-T.B. drugs to adopt by the physician.
This report concerns the frequency and rate chemotherapeutic agents resistant tubercle
bacilli were observed to be present among 86 T,B. patients currently
under-chemotherapy at the Seoul Dispensary, sponsored by The Korean National
Tuberculosis Association. All 86 patients stated at the time of initial examination that
they had not received precious chemotherapy. However, close Questioning, following the
initial examination, revealed that about half of them had received previous Anti-T.B.
drugs, but wore uncertain as to what kind.
The following arc the results of the initial examination of all 86 patients.
Rate of Resistance Anti-73. Drug
Rate of Resistance Anti-T.B. Drug
15.1 % Streptomycin 10γ
20.7% para-aminosalicylic Acid 10γ
16.2% Isonicotinic Acid Hydrazide 10γ
Results of Re-examination after eliminating patients who had taken Anti-T.B. drugs
of unknown type.
Rate of Resistance Anti-T.B. Drug
8.14 % Streptomycin 10γ
9.3 % P.A.S. 10γ
6.24 % U.N.H 10γ
Other conclusions indicated by the examination are as follows:
1. By extent of disease ; the appearance of resistant tubercle bacilli to
chemotherapeutic agents was more frequently observed in far advanced cases (15.1%)
than minimal cases(6.9%) or moderately advanced cases(4.6%)
2. By pathological nature ; the appearance of tubercle bacilli resistant to
chemotherapeutic agents was more frequently seen in cavitary disease(48.8%) than
exudative disease(36.4%) or fibrotic(5.8%) and mixed forms(9.3%).
3. The longer period of time a patients is under chemotherapy seems to parallel his
increased rate of resistant tubercle bacilli.
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